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In january 2008, merck schering plough pharmaceuticals — the maker of both zetia and vytorin — released the results of a study on the effects of the combination of ezetimibe and high-dose simvastatin versus simvastatin alone on the atherosclerotic process in patients with heterozygous familial hypercholesterolemia, called the enhance study.
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In 2008, merck came under fire for the results of their failed enhance trial, which showed that vytorin didn t reduce plaque buildup in the carotid arteries – the main arteries that carry blood to the neck and head – as much as simvastatin alone.
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Income from vytorin accounts for around two-thirds of schering-plough s profits and as such the fate of this reorganisation and the company as a whole depends largely on its fortunes.
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vytorin is a pill that combines zetia with a statin.